Inhibiting key proteins can prolong life
For many years, prolonging life has always been the goal of human pursuit. The latest study found that inhibiting the expression of key proteins to improve the body's autophagy mechanism may achieve life extension.
In 2009, Tamotsu Yoshimori, a researcher from Osaka University, identified a special protein factor, Rubicon, which can inhibit the process of autophagy through the key steps of inhibiting autophagy. Later, in a study published in the international journal Nature Communications, the researchers found that the expression level of Rubicon in different animal tissues was correlated with age.
The process of autophagy will promote the degradation of damaged cellular components, while also reducing the occurrence of various diseases related to cellular stress and dysfunction. Recently, researchers have found that reducing the level of autophagy is directly related to the aging progress of the animal body. There are currently many ways to increase the autophagy process of the aging animal body, which can slow down the aging process of the body.
Researcher Yoshimori pointed out that Rubicon is believed to effectively inhibit the process of autophagy, thus reducing Rubicon in mice can help slow down the occurrence of autophagy-related liver diseases. Therefore, the researchers speculate that Rubicon may use it to interact with the body. The interaction of the phagocytosis process directly affects the aging of the body. In this study, researchers found that multiple aging animal models (nematodes, fruit flies and mice) tissue in the Rubicon level will increase, when inhibiting Rubicon express, all animal models show the body autophagy activity increased, which will significantly improve multiple age related factors, and can extend the life of nematodes, fruit flies.
The researchers pointed out that the expression of Rubicon in the model animal body will cause its age-related exercise ability to decrease, and its level of fibrosis will also decrease. More importantly, the researchers found that the expression of Rubicon protected aging mice from the tendency to induce Parkinson's disease. Since the increase of Rubicon level will lead to the decrease of autophagy level in aging animals, the inhibition of Rubicon expression may be expected to achieve the goal of extending the healthy life of human beings in the future.
In 2009, Tamotsu Yoshimori, a researcher from Osaka University, identified a special protein factor, Rubicon, which can inhibit the process of autophagy through the key steps of inhibiting autophagy. Later, in a study published in the international journal Nature Communications, the researchers found that the expression level of Rubicon in different animal tissues was correlated with age.
The process of autophagy will promote the degradation of damaged cellular components, while also reducing the occurrence of various diseases related to cellular stress and dysfunction. Recently, researchers have found that reducing the level of autophagy is directly related to the aging progress of the animal body. There are currently many ways to increase the autophagy process of the aging animal body, which can slow down the aging process of the body.
Researcher Yoshimori pointed out that Rubicon is believed to effectively inhibit the process of autophagy, thus reducing Rubicon in mice can help slow down the occurrence of autophagy-related liver diseases. Therefore, the researchers speculate that Rubicon may use it to interact with the body. The interaction of the phagocytosis process directly affects the aging of the body. In this study, researchers found that multiple aging animal models (nematodes, fruit flies and mice) tissue in the Rubicon level will increase, when inhibiting Rubicon express, all animal models show the body autophagy activity increased, which will significantly improve multiple age related factors, and can extend the life of nematodes, fruit flies.
The researchers pointed out that the expression of Rubicon in the model animal body will cause its age-related exercise ability to decrease, and its level of fibrosis will also decrease. More importantly, the researchers found that the expression of Rubicon protected aging mice from the tendency to induce Parkinson's disease. Since the increase of Rubicon level will lead to the decrease of autophagy level in aging animals, the inhibition of Rubicon expression may be expected to achieve the goal of extending the healthy life of human beings in the future.
